It is used as a mordant in dyeing. Trivalent antimony compounds are more toxic than the pentavalent because they are excreted slowly., Gastrointestinal disturbance, Headache, Dizziness, Weakness, Kidney injury may occur. These therapeutic doses may be compared with 5 mg/person/day, the rate of respiratory intake of antimony considered safe for workers exposed to various antimony compounds. D-Antimony potassium tartrate. Pentostam is available as a 33% solution (equivalent to 10% SbV +) [11] or 100 mg SbV +/ml [8], which should be stored in a refrigerator and administered intramuscularly or intravenously. (USCG, 1999). The chlorinated hydrocarbon tetrachloroethylene has been used since the 1920s in the treatment of hookworm infection. Antimony potassium tartrate hydrate is a compound used in the treatment of schistosomiasis. Antimony is found in all tissues and organs of “unexposed” people. Nó là muối kali và antimon của axit tartaric. This section provides a listing of alternate names for this chemical, At the emergency department his wife was carefully questioned and informed that unless she told what she had given him, he might die. Potassium antimony(III) oxide tartrate trihydrate extra pure. Analysis of 315 electrocardiograms taken on 100 patients during various stages of treatment with tartar emetic and Fuadin for schistosomiasis revealed one or another abnormality in 11–99% of the patients. The chemical formula of Antimony Potassium Tartrate has evolved along with the progressing in structural analysis systems; it was orig inally known with the formula set out in Merck Index 8th edition,1968 and later with the currently worldwide accepted 2- antimony atom formula set out in Merck Index 11 th edition,1989. Although sodium antimony dimercaptosuccinate and ammonium antimony gluconate showed similar or even higher efficacy than PAT in animal infection, and were somewhat better tolerated by humans, an important shortcoming was that both drugs lacked stability in solution, which hindered their further use in the treatment of schistosomiasis (Chen et al., 1958; Hsu et al., 1960; Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, 1960a; National Schistosomiasis Research Committee, 1959). Antimony potassium tartrate is the most potent and most toxic of the trivalent antimony compounds. Recently, Sanez et al. "c" indicates that although not listed by name and CAS number, this chemical is reportable under one or more of the EPCRA section 313 chemical categories. Chelation treatment was not administered. It is used as a mordant in dyeing. It may also be used in the preparation of novel Sb(III)-containing polyanions by reacting with trilacunary Keggin-type polyanions. tartar emetic. It is hazardous, so the first aid measures and others should be known. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. BAL chelation continued for 10 days with decreasing doses from 600 mg/day to 200 mg/day. Potassium Antimony Tartrate, … At autopsy of persons who have died following ingestion of a large dose, ulcerations usually are found in the esophagus and stomach but not in the intestine. every 4–6 h. He tolerated BAL very badly and instead DMSA chelation was started 23 h after admission. A dose of 10 mg/kg for 30 days was found to be highly effective (almost 100% cures), but there were 12% deaths and 4% relapses. See 50 Federal Register 13456 (April 4, 1985). 58 / Monday, March 26, 2012 / Rules and Regulations . Bephenium, a quaternary ammonium compound formulated as the hydroxynaphthoate, is effective against several nematodes, including Asc. Copyright © 2021 Elsevier B.V. or its licensors or contributors. It finds application in medicine as an expectorant and a nauseant. This page contains information on the chemical Antimony potassium tartrate including: 41 synonyms/identifiers; U.S. Code of Federal Regulations Title 49 Section 172 shipping regulations and proper shipping name; USDOT 2008 Emergency Response Guidebook initial response information. Type Small Molecule Groups Experimental Structure Antimony potassium tartrate Accession Number DB15587 Description. Company Identification: Fisher Scientific One Reagent Lane Fair Lawn, NJ 07410 28300-74-5 - WBTCZEPSIIFINA-MSFWTACDSA-J - Antimony potassium tartrate [USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Antimony potassium tartrate was once used as an emetic for treating patients poisoned by a wide variety of compounds. By continuing you agree to the use of cookies. Potassium antimony (III) tartrate hydrate https://comptox.epa.gov/dashboard/DTXSID5049023 European Chemicals Agency (ECHA) The usual dose of tartar emetic for treating S. nasalis in sheep and cattle is 2 mg/kg daily during 6 days or 3.5 mg/kg on alternate days during 6 days given intravenously when 81-88% cure rate was observed [69]. 77, No. [21] found that the drug may be given at a dose of 20 mg/kg daily for 85 days to achieve successful treatment of leishmaniasis. Fatty degeneration in the liver, but no effects in the kidney, was recorded in an inhalation exposure study on guinea pigs (Dernehl et al., 1945). Lower Explosive Limit (LEL): data unavailable, Upper Explosive Limit (UEL): data unavailable, Autoignition Temperature: data unavailable, Vapor Density (Relative to Air): data unavailable, National Oceanic and Atmospheric Administration, Antimony potassium tartrate trihydrate (28300-74-5). CAS # EC Number Hill Formula Chemical Formula Molar Mass 28300-74-5 234-293-3 C₈H₄K₂O₁₂Sb₂ * 3 H₂O K₂(SbO)₂C₈H₄O₁₀ * 3 H₂O 667.89 Patients <2 or >45 years with signs of advanced VL and/or severe malnutrition are at higher risk of death during antimonial therapy.22,98 Patients should be closely monitored through serum chemistry, complete blood counts and electrocardiography. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. 58 / Monday, March 26, 2012 / Rules and Regulations 07/22/2020 EN (English US) 6/8 Potassium Antimony Tartrate, Trihydrate (28300-74-5) ErC50 (algae) 206 mg/l (OECD 201: Alga, Growth Inhibition Test, 72 h, Pseudokirchneriella subcapitata, However, in such cases where the treatment is extended beyond 30 days, the incidence of cardiac toxicity is increased due to a cumulative dose pressure of the drug. Potassium antimony(III) tartrate hydrate may be used as a standard during the quantification of Sb species present in the juices by HPLC. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. duodenale and has no useful effect against other intestinal worms. Each dose should be given 2 hr after a light meal and the patient should remain recumbent for 1 hr after treatment (AMA, 1977). pregnancy, upcoming surgery, etc. ), allergies, pre-existing diseases, and current health conditions (e.g. In subacute cases, fatty degeneration of the liver, kidney, and heart may be present; degenerative changes in the nervous system are less common. 1-2H 2 O. Lately, a lot of oral treatments were used. The treatment may be repeated if required [12]. Contents. 28300-74-5, EC Number 234-293-3. Office of Response and Restoration, Further symptoms of exposure include nervous complaints (i.e., irritability, dizziness, muscular and neurological pain). *Please select more than one item to compare. Following intravenous injection of tartar emetic, only about 2.5% of the dose was recovered from the urine during the first 24 hr. Hợp chất này từ lâu đã được biết đến như một chất xúc tác mạnh mẽ, tan trong glyxerol nhưng không tan trong cồn. With the objective to develop new antimonials with enhanced therapeutic and safety profiles (National Schistosomiasis Research Committee, 1959), different trivalent antimonials, including tartar emetic derivatives, mercaptan antimonials, stibophen, quinoline antimony, aryl stibonate, stibinyl derivatives and antimony glycerate, were investigated for antischistosomal properties (Chu et al., 1962; Hsiao et al., 1962; Huang, 1979; National Schistosomiasis Research Committee, 1959). These drugs were effective but toxic and have to be given parenterally. followed by oral 100 mg DMPS 3 times per day for 10 days followed by 3 times 50 mg per day for another 10 days. In fact, the resemblance is so close that a distinction may be impossible unless the cause is known as the result of history or chemical analysis. These included sodium stibogluconate (2), meglumine antimoniate (3), derivatives of stibanilic acid (stibamine, 4), stibacetin (5), ethyl stibamine (a mixture of 4, 5, antimonic acid and Et2NH in a molar ratio of 1:2:1:3 with 41-44% of fivevalent antimony content) and urea stibamine (6) have been used to treat kala-azar, cutaneous and mucocutaneous leishmaniasis in man. The rate of recovery fell only very slowly in subsequent days (Boyd and Roy, 1929). During baking a cake after an old recipe tatar cream was by mistake exchanged with tatar emetic, about 6 g were used. Get contact details & address of companies manufacturing and supplying Antimony Potassium Tartrate, 28300-74-5 across India. Usually this dose schedule provides high cure rates. lower incidence of cardiac arrhythmia) and was easier to administer, but was less efficacious when compared to PAT (Xiao, 2000). Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 1997. It can react with strong oxidizing agents. The technique requires the skills of a specialized medical professional. In Brazil an adult dose of 17-28 mg/kg administered intramuscularly daily for 10-20 days is recommended for patients suffering from cutaneous and mucocutaneous leishmaniasis caused by L. braziliensis braziliensis [8,13b,18,19]. Her gastrointestinal conditions normalized over about 2 weeks. The exact mechanism of its action in the worm is unknown, but it is thought to produce paralysis of the adult worm, resulting in its detachment from the vein wall. SAFETY DATA SHEET: ANTIMONY POTASSIUM TARTRATE ANTIMONY POTASSIUM TARTRATE A816.10 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 antimony potassium tartrate nedir ve antimony potassium tartrate ne demek sorularına hızlı cevap veren sözlük sayfası. MSDS Name: Antimony potassium tartrate trihydrate Catalog Numbers: A867-250, A867-500 Synonyms: Antimonate(2)-, bis(mu-tartrato(4-))di-, dipotassium, trihydrate; Antimonyl potassium tartrate; Potassium antimonyl tartrate; Tartaric acid, antimony potassium salt. including trade names and synonyms. Similarly for treating S. mattheei infection in sheep and cattle, stibophen has been given at a dose of 5-10 mg/kg, intramuscularly for 3-10 days [70,71]. (NTP, 1992). Long-term peroral exposure to high doses of antimony may also induce signs of liver toxicity. Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. It is marketed in tablets of 600 mg. There is some controversy about the curative dosage schedule of this drug. A dose of 20 mg/kg for 15 days of the drug was equally effective. pregnancy, upcoming surgery, etc. The development of less toxic pentavalent antimonials by Brahmachari in 1920 subsequently led to the synthesis of sodium stibogluconate (SSG) in 1945. In Sudan it costs 40 US cents per tablet, this is mainly due to new manufacturers in Korea, China, Egypt, Sudan, Brazil, and other countries. Synonyms: Antimony potassium tartrate, Potassium antimony tartrate, Tartar emetic Chemical Formula: K₂(SbO)₂C₈H₄O₁₀ * 3 H₂O Molar Mass: 667.89 g/mol EC Number: 234-293-3 CAS #: 28300-74-5 Hill Formula: C₈H₄K₂O₁₂Sb₂ * 3 H₂O It also reacts with acids, salts of heavy metals, albumins, soap and tannins. Click the link for more information. He had been drinking in the night. (Iffland & Bösche, 1987). ), acacia, antipyrene and mercury bichloride. Mines approved respirator (USCG, 1999). 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