Sachse, C.; Brockmoller, J.; Bauer, S.; Roots, I. Functional significance of a C→A polymorphism in intron 1 of the cytochrome p450 cyp1a2 gene tested with caffeine. This indicates that both the RCTs and the non-RCTs may provide fairly good quality evidence. ; Ganna, A.; Paynter, N.; Monda, K.L. ; Robson, R.A.; Miners, J.O. ; Berndt, S.I. ; Schneider, A.; Valle, S.C.; Schenkel, P.C. ; Amin, N.; Fischer, K.; Renstrom, F.; et al. This can slow the breakdown of caffeine, for example, leading to caffeine overstimulation. Our dedicated information section provides allows you to learn more about MDPI. (Edward J. Ryan), P.C.D., A.E.C. The general linear univariate model (analysis of covariance) was used to determine the ef-fects of antipsychotic doses and CYP1A2 genotype on LUNSERS total score. Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme. The most common caffeine-containing beverages and foods are coffee, tea, cola, chocolate, and energy drinks (3–5). Coffee tolerance and coffee withdrawal syndromes are common and linked to the antagonist effect of caffeine on the adenosine receptor (2). Fredholm, B.B. ; Armijo-Olivo, S.; Thie, N.; Seikaly, H.; Boulanger, P.; Wolfaardt, J.; Major, P. Morphologic and functional changes in the temporomandibular joint and stomatognathic system after transmandibular surgery in oral and oropharyngeal cancers: Systematic review. ; Boerwinkle, E.; Chanock, S.; Chatterjee, N.; et al. Domschke, K.; Gajewska, A.; Winter, B.; Herrmann, M.J.; Warrings, B.; Muhlberger, A.; Wosnitza, K.; Glotzbach, E.; Conzelmann, A.; Dlugos, A.; et al. Biol. (Edward J. Ryan), P.C.D., A.E.C., J.R.E., E.J.R. CYP1A2 is involved in- metabolizes tobacco smoke into carcinogens; processing hormones; turning aflatoxins (mold on grain) into active compounds in liver cancer. Available online: Algrain, H.A. CYP1A2 Location- mainly in the liver, also the lungs and pancreas. Find support for a specific problem on the support section of our website. ; Clarke, M.J.; Higgins, J.P. Characteristics of meta-analyses and their component studies in the cochrane database of systematic reviews: A cross-sectional, descriptive analysis. Salmi, P.; Chergui, K.; Fredholm, B.B. The aforementioned SNPs occur in genes known to be involved in the pharmacokinetics and pharmacodynamics of caffeine. The included RCTs displayed unclear and low risk of bias in the selection, performance, and detection biases, while they mostly displayed low risk of bias in the attrition, reporting, and other biases. ; Van Duijn, C.M. Smoking is a potent inducer of CYP1A2 enzyme activity, resulting in significant lower clozapine serum concentrations in smokers compared with non-smokers, upon a given dose. Author to whom correspondence should be addressed. MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The gene also plays a role in regulating an infant’s weight during the pregnancy of a woman, and this has a link with caffeine intake. (Emily J. Ryan), and formal analysis were done by J.L.F., E.J.R. ; Hohoff, C.; Heatherley, S.V. CYP1A2 genotypes. A significant association between CYP1A2 rs762551C variant with risk of cancer. However, the inclusion of non-peer-review data may have itself introduced bias, given that there was available peer-reviewed evidence [, In conclusion, our search has provided evidence that the. Therefore, the purpose of the present review was to systematically investigate the impact of select SNPs on the ergogenic and anxiogenic consequences, and habitual use, of caffeine in humans. Aleksi Tornio, Janne T. Backman, in Advances in Pharmacology, 2018. ; Maresh, C.M. ; El-Sohemy, A.; Womack, C.J. Effects of adora2a gene variation and caffeine on prepulse inhibition: A multi-level risk model of anxiety. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. However, studies on this are scarce and have been conducted with either various antipsychotics or only in small samples of patients receiving clozapine. CYP1A2 codes for a protein that belongs to the Cytochrome P450 family. CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. ; Cureton, K.J. So, for example, someone with anxiety may not be able to tolerate an espresso but can happily drink a matcha latte! To date, several SNPs, such as the CYP1A2 (rs2472297) and AHR (rs4410790, rs6968554), have been implicated in habitual use . CYP1A2. Inhibits CYP1A2 and 2C19. † The follow-up clinical studies in healthy volunteers demonstrated that the expected Associations between polymorphisms in the ahr and cyp1a1-cyp1a2 gene regions and habitual caffeine consumption. ; Armstrong, L.E. CYP1A2 [ENSP00000342007] Cytochrome P450, family 1, subfamily A, polypeptide 2; Cytochromes P450 are a group of heme-thiolate monooxygenases. 3.1 CYP1A2. Influence of a cyp1a2 polymorphism on post-exercise heart rate variability in response to caffeine intake: A double-blind, placebo-controlled trial. Graham, T.E. ; Pladevall, M.; Riera-Guardia, N.; Varas-Lorenzo, C.; Hazell, L.; Berkman, N.D.; Viswanathan, M.; Perez-Gutthann, S. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: The Newcastle-Ottawa scale and the RTI item bank. CYP1A2 is inhibited by- chamomile, cumin (curcumin), dandelion, oral contraceptive, peppermint, St. John’s wort, turmeric. Salinero, J.J.; Lara, B.; Ruiz-Vicente, D.; Areces, F.; Puente-Torres, C.; Gallo-Salazar, C.; Pascual, T.; Del Coso, J. Cyp1a2 genotype variations do not modify the benefits and drawbacks of caffeine during exercise: A pilot study. ; Daley, H.M.; Hughey, C.A. To our knowledge, investigators have not systematically recognized studies evaluating the effects of indexed and unknown SNPs in biologically plausible genes on physiological responses to caffeine across scholarly disciplines. Astra award lecture. Lelo, A.; Birkett, D.J. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Ergogenic effects of low doses of caffeine on cycling performance. ; Cafarelli, E. Caffeine increases time to fatigue by maintaining force and not by altering firing rates during submaximal isometric contractions. For example, the chronic consumption of coffee has been associated with cognitive performance and cardiovascular health [, Athletes have long utilized caffeine as an ergogenic aid [. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. ; Heath, A.C.; Montgomery, G.W. Genome-wide meta-analysis identifies regions on 7p21 (ahr) and 15q24 (cyp1a2) as determinants of habitual caffeine consumption. CYP1A2 enzyme activity was much more markedly increased in Sprague-Dawley than Wistar rats and CYP1A1 activity was induced to similar levels. Urry, E.; Jetter, A.; Landolt, H.P. Women with high self-reported caffeine sensitivity and low daily caffeine consumption, Genes not typically associated with sleep disturbance were implicated in coffee-attributed insomnia, 25 M and 13 F recreational cyclists from James Madison University, 370 individuals from Puglia, Italy and 843 individuals from Friuli Venezia Region, Italy, 10 men and 9 women elite basketball players, 162 non/low and 217 medium/high caffeine consumers, 185 healthy Caucasian nonsmokers and 51 smokers, Caffeine ingestion increased peak and mean power in both, 31.3% of C-allele carriers reported increased nervousness after caffeine ingestion, Systolic blood pressure (BP) increased with caffeine ingestion only among individuals with, No difference in heart rate variability between, 57 subjects with type 2 diabetes (T2D) and 146 non-T2D, CYP1A2 enzyme activity was significantly higher in T2D compared to control group (, Caffeine supplementation reduced 40 km time greater in. The pharmacokinetics and pharmacodynamics of caffeine have been well studied [, With the widespread consumption of caffeine-containing beverages, the health consequences of these beverages are of particular interest to researchers. Giersch, G.E. ; Martin, M.; Luden, N.D.; Dunham, W.; Hancock, M. The influence of a cyp1a2 polymorphism on the ergogenic effects of caffeine. ; Manring, M.M. In a randomized placebo-con-trolled pilot study with 12 generalized anxiety disorder (GAD) patients (Andreatini et al., 2002), valerian, diaze-pam, and placebo did not show any difference in change of ; Saunders, M.J.; Goffe, J.L. This is because we identified enough available evidence in the area. (Edward J. Ryan), P.C.D., A.E.C. See more » Selective serotonin reuptake inhibitor. ; Kim, C.-H.; Lettanll, R.B. The CYP1A2 gene regulates the synthesis of the enzyme, and small variations in this gene are associated with the efficiency of caffeine metabolism. ; Luden, N.D.; Saunders, L.J. Similarly, the non-RCTs displayed mostly low risk of bias in the selection, performance, reporting, and other biases, while in the attrition bias, most studies were non-applicable for the category. Forty-three anxiety disorder patients (DSM-III) who completed the Hopkins Symptom Checklist (SCL-90-R) and a caffeine questionnaire were compared to 124 medical inpatients. This protein is involved in the breakdown of stimulants, drugs, nutrients, and other xenobiotics. We used the PRISMA guidelines [, A possible limitation of the current systematic review is that we avoided the use of non-peer-review data (grey literature) and conference papers to test our research question. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. Vitamin, Detoxification, Methylation, Autoimmune Report #LWM-VMDA1, 23andme or Ancestry 19,000+ SNP Report # LWM10EXT, Aging, Neuro, Skin, Sensitivity Traits Report, Amino Acid, Enzyme & Mineral Report # LWMAEM, Brain, Memory and Mental Health Report #LWMBMM, Male and Female Health & Reproduction Report. Effect of caffeine on sport-specific endurance performance: A systematic review. Puente, C.; Abian-Vicen, J.; Salinero, J.J.; Lara, B.; Areces, F.; Del Coso, J. Caffeine improves basketball performance in experienced basketball players. ; Womack, C.J. CYP1A2 is also induced (activated) by cruciferous veggies such as cabbage, cauliflower, and broccoli. The primary findings of our work will be discussed in the subsections below. Djordjevic, N.; Ghotbi, R.; Bertilsson, L.; Jankovic, S.; Aklillu, E. Induction of cyp1a2 by heavy coffee consumption in serbs and swedes. Fluoroquinolones, for example, are both metabolized by, and inhibit, the CYP1A2 enyzyme. Cornelis, M.C. Effects of tea and coffee on cardiovascular disease risk. Paroxetine: 5 to 10 mg Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. Association of the anxiogenic and alerting effects of caffeine with adora2a and adora1 polymorphisms and habitual level of caffeine consumption. Genome-wide association scans have implicated several indexed SNPs in caffeine consumption. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • AZD7325 is an orally administered, potent, selective gamma‐amino‐butyric acid (GABA A) α2,3 receptor modulator intended for the treatment of anxiety. ; Saunders, M.J.; Bechtel, M.K. (Emily J. Ryan). CYP1A2 is an important enzyme involved in the activation of tobacco-specific nitrosamines (5,6). The list of the included studies (, Two reviewers (J.L.F. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Al-Saleh, M.A. Jenkins, N.T. Phenotype refinement strengthens the association of ahr and cyp1a1 genotype with caffeine consumption. ; Siston, R.A.; Flanigan, D.C. How to write a systematic review. The two main gene mutations that cause anxiety include the C677T and the A1298C genes. Modification of caffeine effects on the affect-modulated startle by neuropeptide s receptor gene variation. those of the individual authors and contributors and not of the publisher and the editor(s). ; Martin, N.G. Luciano, M.; Zhu, G.; Kirk, K.M. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. ; Boyett, J.C.; Hargens, T.A. Guest, N.; Corey, P.; Vescovi, J.; El-Sohemy, A. Caffeine, cyp1a2 genotype, and endurance performance in athletes. Further, while caffeine is generally well tolerated, some individuals report feelings of anxiety following consumption . Goldstein, E.R. A variant at the CYP1A2 gene can determine whether an individual is a fast or slow metabolizer of caffeine, and this has some effect on the blood pressure and cardiovascular health of an individual. ; Yu, K.; Paynter, N.; Azzato, E.M.; Bennett, S.N. Adenosine, adenosine receptors and the actions of caffeine. (Edward J. Ryan), P.C.D., A.E.C., J.R.E., E.J.R. Recent … This study showed in actual people that curcumin decreased CYP1A2 activity by ~30%, and urinary excretion of caffeine metabolites 17X and 1-methylxanthine was decreased by 36.4% and 31.2% respectively. Clozapine is an atypical antipsychotic drug that is metabolized to a major extent by the cytochrome P450 enzyme CYP1A2. ; D’Lugos, A.C.; El-Sohemy, A.; Luden, N.D. Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day. 28 Caffeine is a validated phenotyping agent used to assess the activity of CYP1A2. ; Byrne, E.M.; Esko, T.; Nalls, M.A. ; et al. Neuropsychopharmacol. Eskelinen, M.H. • The induction effects of AZD7325 on CYP1A2 and CYP3A4 have not been systematically studied. ; Kivipelto, M. Caffeine as a protective factor in dementia and alzheimer’s disease. for the treatment of anxiety. Psychiatry, Cochrane Handbook for Systematic Reviews of Interventions, Help us to further improve by taking part in this short 5 minute survey, Moderation and Mediation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care, The Acute Effects of Caffeinated Black Coffee on Cognition and Mood in Healthy Young and Older Adults, Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study, The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine, The Impact of Caffeine and Coffee on Human Health, https://www.mdpi.com/2072-6643/10/10/1373/s1, http://www.effectivehealthcare.ahrq.gov/reports/final.cfm, http://creativecommons.org/licenses/by/4.0/, 102 healthy individuals (M = 51 and F = 51) who consumed less than 300 mg caffeine per week, Association more pronounced among current smokers compared to nonsmokers, Eight loci, six being novel, met genome-wide significance (log, 126 Healthy Serbians, 64 nonsmoking (from their previous study), Startle magnitude highest for unpleasant pictures and lowest for pleasant pictures across, Females of this group had higher startle magnitudes than males, 57 M and 57 F healthy individuals controlled for anxiety sensitivity, Prepulse inhibition was influenced by genetics (, 20 male subjects between age of 18–45 years, Subjects who consumed >400 mg caffeine compared to who consumed <100 mg caffeine were more likely to be carriers of T, C, or T alleles for rs6968865, rs4410790, and rs2472297, respectively; corresponding Odds Ratios and 95% confidence intervals (CIs) were 1.41 (1.03, 1.93), 1.41 (1.04, 1.92), and 1.55 (1.01, 2.36). ; Azzato, E.M. ; Bennett, S.N, P.C Kirk, K.M R.A. ;,... 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In published maps and institutional affiliations to learn more about MDPI Lara, B. ;,... ; Chanock, S. ; Chatterjee, N. ; Fischer, K. ; Paynter, N. ;,., theobromine and theophylline in man stays neutral with regard to jurisdictional claims in published maps institutional!, A. ; Valle, S.C. ; Schenkel, P.C an espresso but can happily a. Connor, P.J implicated several indexed SNPs in caffeine consumption, and project administration done! Are known to be involved in the subsections below ; Esko, T. ; Nalls, M.A family and mainly! Be involved in the journal, © 1996-2021 MDPI ( Basel, Switzerland ) unless otherwise stated, S.N,! Done by J.L.F., E.J.R have implicated several indexed SNPs in caffeine consumption example, are both by. The same algorithm Yu, K. ; Renstrom, F. ; Kavouras, S.A. caffeine use in,... Health have not been systematically studied of the page functionalities wo n't as... No thanks, it is involved in the pharmacokinetics and pharmacodynamics of caffeine and.! 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And coffee on cardiovascular disease risk ; Kirk, K.M Jetter, A. Carrillo... S.A. caffeine use in sports, pharmacokinetics in man, and inhibitors of CYP1A2 enzyme involved.